"Improving the Utility and Translation of Animal Models for Nervous System Disorders" ed. by Diana E. Pankevich, at al.

ISBN: 0309266335

Category: Study


Posted on 2013-02-27. By anonymous.

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"Improving the Utility and Translation of Animal Models for Nervous System Disorders" ed. by Diana E. Pankevich, Theresa M. Wizemann, and Bruce M. Altevogt
Forum on Neuroscience and Nervous System Disorders; Board on Health Sciences Policy; Institute of Medicine
NASPress | 2013 | ISBN: 0309266335 9780309266338 | 110 pages | PDF | 5 MB

This issue discusses potential opportunities for maximizing the translation of new therapies from animal models to clinical practice. The primary focus is to examine mechanisms for increasing the efficiency of translational neuroscience research through discussions about how and when to use animal models most effectively and then best approaches for the interpretation of the data collected.

The objectives are: discuss key issues that contribute to poor translation of animal models in nervous system disorders, examine case studies that highlight successes and failures in the development and application of animal models, consider strategies to increase the scientific rigor of preclinical efficacy testing, explore the benefits and challenges to developing standardized animal and behavioral models.
The issue also identifies methods to facilitate development of corresponding animal and clinical endpoints, indentifies methods that would maximize bidirectional translation between basic and clinical research and determines the next steps that will be critical for improvement of the development and testing of animal models of disorders of the nervous system.

Contents
1Introduction and Overview
2Evaluation of Current Animal Models
3Translation from Animal Models to the Clinic: Case Examples from Neuroscience Research
4Perspectives on Standardization
5Perspectives on Corresponding Animal and Clinical Endpoints
6Addressing the Translational Disconnect
7Summary of Workshop Topics
A: References
B: Workshop Agenda
C: Registered Attendees
with TOC BookMarkLinks

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