Aspartic Acid Proteases as Therapeutic Targets (Methods and Principles in Medicinal Chemistry)

ISBN: 3527318119

Category: Technical

Tag: Science/Engineering


Posted on 2013-08-09. By anonymous.

Description


Aspartic Acid Proteases as Therapeutic Targets (Methods and Principles in Medicinal Chemistry) by Arun K. Ghosh, Raimund Mannhold, Hugo Kubinyi and Gerd Folkers
English | 2010 | ISBN: 3527318119 | 640 pages | PDF | 7,5 MB

In this ground-breaking practical reference, the family of aspartic acid proteases is described from a drug developer's perspective. The first part provides a general introduction to the family of aspartic acid proteases, their physiological functions, molecular structure and inhibition.

Parts two to five present various case studies of successful protease inhibitor drug design and development, as well as current and potential uses of such inhibitors in pharmaceutical medicine, covering the major therapeutic targets HIV-1 protease, renin, beta-secretase, gamma-secretase,plasmepsins and fungal proteases.
A ready reference aimed primarily at professionals in the pharmaceutical industry, as well as for anyone studying proteases and their function.


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