HIV Interactions with Host Cell Proteins

ISBN: 3642021743

Category: Uncategorized


Posted on 2011-10-16. By anonymous.

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HIV Interactions with Host Cell Proteins
HIV Interactions with Host Cell Proteins
204 pages | Sep 22 2010 |ISBN:3642021743 | PDF | 5.5 Mb

The authors seek to understand the assembly process of human immunodeficiency virus (HIV) and to develop a vaccine that can effectively neutralize HIV. HIV assembly is a process directed by the viral Gag polyprotein. Gag is a myristoylated precursor protein that is translated in the cytoplasm and then traffics to the plasma membrane or to endosomal vesicles for assembly. The authors have recently described an interaction between Gag and the delta subunit of the AP-3 adaptor protein complex (1). The mechanism and structural basis for this interaction is now under intense study.

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