[PDF] Thermodynamics and Kinetics of Drug Binding, Volume 65 (Methods and Principles in Medicinal Chemistry)

ISBN: 352733582X

Category: Tutorial


Posted on 2017-10-09, by luongquocchinh.

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Author: Gyorgy Keseru, David C. Swinney, Raimund Mannhold, Hugo Kubinyi, Gerd Folkers | Publisher: Wiley-VCH | Category: Medicine | Language: English | Page: 360 | ISBN: 352733582X | ISBN13: 9783527335824 |

Description: This practical reference for medicinal and pharmaceutical chemists combines the theoretical background with modern methods as well as applications from recent lead finding and optimization projects. Divided into two parts on the thermodynamics and kinetics of drug-receptor interaction, the text provides the conceptual and methodological basis for characterizing binding mechanisms for drugs and other bioactive molecules. It covers all currently used methods, from experimental approaches, such as ITC or SPR, right up to the latest computational methods. Case studies of real-life lead or drug development projects are also included so readers can apply the methods learned to their own projects. Finally, the benefits of a thorough binding mode analysis for any drug development project are summarized in an outlook chapter written by the editors.

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